Studies have shown that insulin resistance in diabetic patients can be improved to some extent with treatment, but there is no evidence that insulin resistance can be completely normalized. Weight loss is strongly associated with a reduction in insulin resistance in patients, so weight loss therapy may improve insulin resistance to some extent. There is strong clinical evidence to support the use of short-term intensive insulin therapy in patients with newly diagnosed or short-duration type 2 diabetes mellitus to improve pancreatic beta-cell function and insulin resistance in patients with newly diagnosed type 2 diabetes mellitus. It is recommended that patients with insulin resistance seek prompt medical attention and standardize treatment as prescribed.