Vitiligo is a common acquired pigment loss disease of the skin and mucous membranes. The disease has the possibility of cure, but the treatment process is more lengthy. The cause may be related to genetics, neuropsychiatric, immune and endocrine metabolism, there is no special treatment, patients should be treated in time to help improve the cure rate, common drug therapy includes the following aspects: a. Western medicine therapy: 1. Immunomodulators: autoimmunity as the main pathogenesis, such as tacrolimus ointment and other immunomodulators can affect keratin-forming cells by regulating immune function The immune regulators, such as Tacrolimus ointment, can affect keratinocytes by regulating immune function, promote the growth of melanocytes, and create an environment conducive to melanocyte migration, thus treating and reducing disease recurrence to some extent. And such drugs generally have small adverse reactions and do not produce side effects such as skin atrophy and capillary dilation; 2, corticosteroids: the application of hormones can stimulate melanocytes to produce melanin and inhibit melanocyte autoantibodies to achieve the purpose of inhibiting the destruction of melanocytes, which helps control the disease; 3, vitamin D derivatives: can regulate melanocytes, human keratinocyte function, increase intracellular calcium levels, thus helping vitiligo lesions to recolor. Second, the Chinese medicine: can apply with the liver and kidney tonifying, qi and blood activation of jade therapy spirit particles for vitiligo, help to increase the pigmentation of skin lesions, but also can directly act on the cellular metabolism of tyrosinase and melanocytes, help to regulate the immune status of the body, help vitiligo treatment, and to some extent control the development or recurrence of disease. It is recommended that patients take medication under the guidance of a professional doctor, in addition to physical therapy such as narrow spectrum medium wave ultraviolet light, 308nm excimer laser, or surgical treatment. If a single drug, physical or surgical treatment cannot achieve satisfactory results, a combination of two or more methods can be used.