Female pituitary adenoma infertility is associated with hyperprolactinemia (HP). The main points are as follows: 1. HP affects ovarian function interfering with the production of steroid hormones and decreasing the production of progesterone, thus causing anovulation; 2. HP acts on the pituitary gland, decreasing the sensitivity of the pituitary gland to gonadotropin-releasing factor (GnRH) and reducing the secretion of gonadotropin; 3. HP acts on the hypothalamus, inhibiting the synthesis and release of GnRH, blocking the positive feedback effect of estrogen and the disappearance of LH pulse peak disappears, leading to non-ovulation. It has been reported that hyperprolactinemia can also affect follicular development, difficulty in ovulation, and interfere with fertilization and embryonic development leading to infertility or habitual abortion. Serum prolactin has become one of the causes of infertility, which has been increasing year by year in recent years, and serum prolactin is often found eventually after other causes of infertility have been ruled out, as it is easily overlooked by physicians. Therefore, to avoid such a situation, symptoms should be promptly diagnosed and treated by a specialist in neurosurgery. Experts point out that serum prolactin is secreted in paroxysmal pulses and varies in a diurnal cycle, peaking in the morning, so blood should be drawn on an empty stomach at 8:00 to 10:00 am. Treatment of pituitary prolactinoma inhibits or destroys the progression of tumor cells, prevents and reduces the compression of normal pituitary tissues by the tumor, in order to restore and protect the function of pituitary gland, inhibits the tumor from secreting excessive serum prolactin, thus correcting and improving the inhibitory effect on pituitary gland and ovaries and restoring the function of gonadal axis. For this condition, dopamine agonists are mostly used clinically to treat pituitary tumors, which can not only inhibit the synthesis and release of serum prolactin, but also specifically reduce the amount of DNA and RNA in prolactinoma cells, inhibit cell nuclear division, increase the intracellular degradation of serum prolactin, cause the tumor to shrink rapidly, effectively inhibit overflow, increase the pituitary response to folliculopoietin (FSH), luteinizing hormone (LH ) release and luteinizing hormone (LH) to promote the resumption of ovulation and menstruation to achieve fertility requirements. For patients with infertility, whether male or female, based on the exclusion of peripheral causes, such as abnormal menstruation in women or changes in men such as hypogonadism, thinning hair and delicate skin, it is important to visit the neurosurgery department of a regular hospital. Once it is a PRL pituitary tumor, the majority of patients can resume normal life and solve the infertility problem by choosing the appropriate treatment plan according to their condition.