Uncle Gao, 61 years old, had persistent fever with a maximum temperature of 39℃ for the last 1 week, accompanied by sore throat at the beginning of the disease. The fever persisted and the sore throat spread to the anterior neck area. Finally, the patient’s blood thyroid indicators were abnormal, and a thyroid puncture was performed to confirm the diagnosis of subacute thyroiditis (hereinafter referred to as subacute thyroiditis). Subacute thyroiditis is also known as viral thyroiditis, granulomatous thyroiditis or giant cell thyroiditis. It is usually seen in middle-aged women and is thought to be related to a viral infection. It is often misdiagnosed as a “cold” or “pharyngitis” because of a history of upper respiratory tract infection before the onset of the disease. The pathology of the disease is non-bacterial inflammation that destroys thyroid cells and releases thyroid hormones into the bloodstream, resulting in early manifestations of hyperthyroidism, with fever, sometimes even hyperthermia, up to 39°C or higher, combined with symptoms of hyperthyroidism such as panic, fatigue and excessive sweating, and later hypothyroidism. ”Subthyroiditis is a self-limiting disease that gradually repairs damaged thyroid cells and restores normal thyroid function over the course of 4-6 months or longer. Therefore, there is no need to be overly nervous when you get “subthyroiditis”, as most patients have a good prognosis if they go to a regular hospital for specialist treatment and take rest. Lastly, if your lab tests indicate hyperthyroidism, accompanied by persistent fever and neck pain, be aware that you have subthyroiditis.