Most patients need to take eugenol (also known as levothyroxine sodium tablets) after surgery for thyroid diseases, especially for thyroid cancer patients, who need to take eugenol strictly after surgery to prevent recurrence, however, most patients have great concerns about taking the medicine, thinking that eugenol has big side effects and it is troublesome to wait for the medicine every day, here is some knowledge of eugenol for you. 1, the difference between eugenol and ordinary thyroxine tablets ordinary thyroxine tablets for T3, T4 mixture, eugenol is levothyroxine tablets, i.e., T4. eugenol advantage lies in: (1) on the surface, because the human body at the same time there is a T3, T4, by the T3, T4 mixture made of tablets seems to be very reasonable. However, in fact, the vast majority of T3 in the human body is converted from T4 (we note that the activity of T3 is greater than that of T4), therefore, thyroid cancer patients take more eugenol orally to inhibit the TSH, but it does not make the body of the T3 increase how much, but only the T4 increase, resulting in fewer side effects. (2) Eugenol is not much more expensive in price, more than 30 yuan 100 tablets, I believe any family can afford it. (3) What’s more, the half-life of T3 is 24 hours, while T4 is 1 week. As long as you’ve learned math, you know that the blood concentration you get from taking Eugenol is definitely more stable than that of ordinary thyroxine tablets (in the past, patients taking ordinary thyroxine tablets usually took them twice a day, and the patients’ compliance was even worse). Therefore, ordinary thyroxine tablets have been eliminated at present. 2, benign and malignant oral eugenol dose, time (1) there are many patients with benign thyroid nodules, do not need to do surgery, always want to take drugs to control the growth of nodules, ATA pointed out that for iodine intake in normal areas do not recommend the routine application of thyroxine suppression therapy for benign thyroid nodules, so for this part of the patient, the best way is to take ultrasound examination once every six months. (2) Benign diseases such as nodular goiter should take euthyroid after surgery to keep TSH in the middle and lower 1/3 of the normal range, such as TSH normal reference value of 0.27-4.2, which is in the best between 1-2. The timing should be decided based on the TSH review results. Even if the surgery has little effect on TSH, it is best to take it for six months to a year to be able to inhibit the regeneration of nodules in the remaining thyroid tissue. For patients with subtotal thyroidectomy, the time may be longer, with the possibility of lifelong medication. (3) For malignant diseases, oral eugenol is recommended by the 2011 NCCN guidelines to be used at 2.11ug/KG/day to make the TSH less than 0.1 (complete suppression), and the NCCN guidelines also emphasize that the optimal amount of suppression should be chosen based on the patient’s individual situation (cardiac, osteoporosis, and hyperthyrotoxicity), so that the TSH will be either slightly less than the low limit of normal or slightly higher than the low limit of normal. Of course the amount of remaining thyroid tissue varies, and so does the required dose of eugenol. In Europe and the United States, total resection is used for thyroid cancer, and in China, many patients still have residual thyroid tissue, so 2.11 may refer to the dose for patients with total resection. Therefore, it is important to review the thyroid function and adjust the dose of Eugenol according to the thyroid function. The duration of administration should be strict for at least 5 years, and after 5 years without recurrence, discretionary dose reduction can be considered.