Ibuprofen suppositories are effective approximately 2 hours after rectal administration. If symptoms are not relieved, repeat the dose once at an interval of 4-6 hours, not more than 4 capsules in 24 hours. Clinically, ibuprofen suppositories are mostly used for the treatment of fever due to acute upper respiratory tract infection in children. Individual children may experience dizziness, headache, tinnitus, allergic nephritis, drowsiness and gastrointestinal reactions after using ibuprofen suppositories. Children must be used under the guidance of a doctor when using the drug, always observe the child’s body reaction, and can be treated with physical cooling when the body temperature exceeds 38.5℃. Ibuprofen suppositories are used symptomatically and are forbidden to be used as long-term analgesic or antipyretic medication, while patients should observe the shelf life of the medication or whether there is any deterioration. Therefore, once the child develops symptoms such as slurred speech and general weakness, he or she must be promptly seen by the pediatric department of the hospital.