Because children’s infectious fever is often acute, foreign countries generally advocate the use of antipyretic drugs less, drink more water, let the child recover on their own or combined with physical methods to reduce fever. Some parents in China are anxious about their children’s fever and often give their children antipyretic drugs regardless of their age, which often turns out to be contrary to their wishes. Instead, it is easy to cause adverse consequences, so any antipyretic drugs for children should be used with caution. Parents should master the following principles of medication: 1, low fever without medication: 38.50C is the threshold for medication. According to the World Health Organization’s recommendations, the body temperature is higher than 38 5 ℃ before it is necessary to use antipyretic drugs, below this temperature when the child’s mental state is relatively good, you can continue to observe, do not use antipyretic drugs. When infants and young children start to have a fever, physical methods such as wiping the body with warm water or diluted medical alcohol are preferred to reduce the temperature. 2, the interval between medications can not be short: antipyretic drugs are generally used twice at intervals of more than 4 hours. Each time you take one, if the child takes cold medicine containing antipyretics, then you can no longer use, to prevent the superimposed effect of antipyretics, resulting in adverse drug reactions. 3. Strictly control the time and amount of medication: Generally speaking, do not use more than 3 days in a row. If your child does not improve significantly after taking antipyretic drugs for 3 consecutive days, you need to go to the hospital for consultation. The dosage of antipyretic drugs should be strictly controlled. The dosage of antipyretic drugs for infants and young children is too large and there is a risk of excessive sweating causing deficiency. 4, within 6 months of the baby fever should not use antipyretic drugs to cool down, but should be carried out physical cooling, such as loosening the package quilt, warm water bath, paste antipyretic paste, etc., while more water to the child can make the child cool down. There are two main types of fever-reducing drugs commonly used in children: ibuprofen and acetaminophen. Now there is a new antipyretic and analgesic drug Nimesulide in clinical use. The drug has been marketed in China for many years, and is favored by many parents because it not only reduces fever quickly, but also maintains its antipyretic effect for 8 to 12 hours. However, there have been recent reports of adverse reactions, especially damage to the central nervous system and liver, which can even lead to death in children. These news have been exposed by the media and have aroused close attention to the drug from scholars, experts and the general public at home and abroad. The issue of hepatotoxicity of Nimesulide warrants a high degree of vigilance and should be used with caution in children with previous liver damage. Changes in liver function should be monitored during the use of this drug. The drug should be discontinued as soon as symptoms of liver injury (e.g., anorexia, nausea, vomiting, abdominal pain, fatigue, yellow urine) and abnormal liver function tests appear. By a fluke the vast majority of nimesulide induced liver damage is reversible. Any drug has adverse reactions, Nimesulide can be used in children over 12 years old with fever, and parents of children should not be overly nervous when using this drug, they can closely observe whether their children have abnormal performance, and go to the hospital in time once abnormalities are found.