For the treatment of acute osteomyelitis, the first choice of drugs is based on anti-inflammatory drugs. For acute osteomyelitis, we should combine the application of antibiotics in sufficient quantity for treatment, and it is best to take secretions for bacterial culture and drug sensitivity test. According to the culture test results and drug sensitivity test results, effective antibiotics will be selected to control the infection, such as cefixime for cephalosporins and ofloxacin for quinolones. In addition, for more serious cases of osteomyelitis, repeated flushing with puncture aspirate is required. If it is more serious it may require complete debridement or amputation for treatment. There is also vancomycin, which has a strong effect on Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus, followed by clindamycin. Also if others are suspected, such as gram-negative bacterial infections rifampicin can be applied, and also aminoglycoside antibiotics can be applied.