The absence of menstruation and the absence of pregnancy may be caused by endocrine disorders or by the decline of ovarian function. If the endometrial lining is thickened, progesterone can be given for withdrawal bleeding, and hormone level test can be performed in the first four days of bleeding to understand the function of the ovaries; if the menstruation does not come at an older age, hormone level test can also be performed. Hormone replacement can be performed to adjust menstruation.