In recent years, an increasing number of studies have focused on the relationship between the age of the female partner and the success of assisted reproduction and fetal birth outcomes, but less attention has been paid to male factors, especially the effect of the male partner’s age on pregnancy and delivery outcomes. Because of the physiological effects of age changes in the male partner, genetic mutations that may be deleterious to pregnancy and development may result due to paternal gene expression, especially in middle-aged and older men, on assisted reproductive pregnancy outcomes and on sperm and embryo development. Male age can increase the risk of spontaneous abortion, preterm birth, stillbirth, schizophrenia, autism, low birth weight babies and genetic abnormalities in the female partner There are some studies that have confirmed this. In a French report of 1938 cases treated with conventional IVF for bilateral tubal obstruction, the father’s age over 40 years was an important risk factor for failure to conceive, with a significant superimposed effect when the interaction between male and female age was taken into account and the female partner was ≥41 years old. In another study, it was found that for each additional year of male partner age in couples with male oligospermia, the female partner’s chances of becoming pregnant decreased by 5%. Perhaps the best way to assess the effect of male partner age on pregnancy outcome is to use a donor case, which primarily eliminates the effect of the female partner age variable because the donor is a young, healthy woman. This was found in a study of 1,023 infertile couples undergoing anonymous donor egg cycles. For men aged > 50 years and ≤ 50 years, the female pregnancy rate was 56.0% and 41.3% and the miscarriage rate was 41.5% and 24.4%. The risk of reproductive failure, including miscarriage and increased late-term fetal mortality, increases with male age, and is now thought to be mainly due to impaired spermatogenesis and increased risk of aging, and mutations in male germ cells. Some scholars have suggested that 40 years of age is as high a risk limit for men as it is for women at 35 years of age, and that some vigilance should be exercised in clinical treatment.