Cholecystectomy is a common operation in hepatobiliary surgery. What are the effects on the body after cholecystectomy? What are the after-effects? The following combined with the relevant literature, to make some simple summary. First, it can cause indigestion, the gallbladder has the function of storing and concentrating bile, after gallbladder removal, bile continuously enters the bile duct, enters the intestine, lack of food and gastric acid synthesis, under the dilution of bile can appear indigestion, diarrhea, bloating and other symptoms. Second, bile reflux gastritis, when bile continues to enter the intestine after accumulating in the 12 fingers, it may reflux into the stomach to cause reflux gastritis. After cholecystectomy, the concentration of bile salts decreases, the concentration of bile acids decreases, and the ability to dissolve cholesterol decreases, which leads to the accumulation of cholesterol and the formation of stones. Fourthly, lactation colon cancer. After cholecystectomy, the stimulation of bile acid increases, which can further stimulate the cancer of colonic mucosa.