The drug of choice for the treatment of leptospirosis is penicillin, which is usually administered for about one week, and it is administered at a dose of 400,000 units every 6-8 hours. It is easy to develop Hirschsprung’s reaction when using penicillin for leptospirosis, so it is currently advocated to start with a small dose and gradually increase the dose to 400,000 units later, or use hormones at the same time as penicillin to avoid the occurrence of Hirschsprung’s reaction. Hirschsprung’s reaction is a clinical symptom of penicillin treatment for leptospirosis, which mainly manifests as chills, high fever, increased respiration and heart rate, and even diffuse pulmonary hemorrhage, so it must be paid great attention. If you are allergic to penicillin, you can choose gentamicin or tetracycline.