I see many vitiligo patients every day in the clinic, and when they come, most of them show three colors around the white spots and white spots, the center is white, or red and peeling, or blistered, the surrounding is dark, and then the surrounding is normal skin color, ask about the medical history, most of them have a history of topical use of solutions containing tonicotin. I have a different view on this. The use of a medication containing bone marrow ester type will increase the damage to melanocytes in the early stages of vitiligo. The actual fact is that you will be able to get a lot more than just a few of these. In the early stages of vitiligo, melanocytes are often in the state of immune damage or cytotoxic damage, when melanocytes need to rest and repair, if you use a drug such as osteopontin at this time, the skin will appear phototoxic reaction, manifested as erythema, serious even blisters, erythema, after long-term use, the white spots will appear keratinized, thickened, mossy. Due to the body’s self-protection mechanism, melanocytes are required to secrete melanin to protect the body from the damage of phototoxic reactions, but because the melanocytes are in a pathological state, not only can they not produce melanin, but they will be damaged, and the above-mentioned skin manifestations of chronic phototoxic reactions will appear. If the potion is applied to the surrounding normal skin, the normal skin color will become very dark, forming a very large color difference, so that the skin appearance is also damaged, increasing the patient’s fear and disappointment in the treatment of vitiligo. Nowadays, a considerable number of patients will even mistakenly consider the phototoxic reaction of tretinoin as the efficacy of the drug. Even to pursue this reaction. Indeed, they do not know that such treatment will aggravate vitiligo or delay the treatment of vitiligo. Then when to use bone supplement? If used cautiously on the white spots during the recovery period of vitiligo, it can shorten the treatment time of vitiligo. However, a special reminder is not to apply bone tonicin to normal skin to avoid large color difference and affect the appearance. For stable, long-treated untreated vitiligo to implement melanin restoration surgery early.