In 1937, American physicians mccune and al-bright reported a disease with three major features: multiple osteochondrodysplasia, non-augmented skin brown pigmentation and precocious puberty, which was later named mccune-albright syndrome, a rare clinical disease. The disease alias McCune-Albright Syndrome (MAS), also known as multiple osteochondrodysplasia with precocious puberty syndrome, is characterized by cutaneous café au lait spots, precocious puberty, and multiple osteochondrodysplasia. The disease is sporadic and twice as common in women as in men. Zhang Lei, Department of Maxillofacial Surgery, Peking University Oral Hospital