If you have tonic pupils, it is important to detect them in a timely manner and to prevent them early. If you have a case of tonic pupil, it is recommended that you receive treatment at a specialized five-eye hospital as soon as possible. I. Medical history Patients with pupillary abnormalities are less likely to discover them on their own, but are mostly discovered by others or when looking in the mirror. Attention should be paid to the time of discovery, whether it is persistent or intermittent, how it is discovered, whether the condition progresses quickly or slowly, whether it is monocular or bilateral, or alternating, etc. The history of pupillary abnormalities should be taken with attention to systemic diseases such as hypertension, aneurysm, arteriosclerosis, cerebrovascular disease, diabetes, syphilis, hyperthyroidism, and chronic alcoholism, which can easily be combined with extraocular muscle paralysis. Also note neck disease, lung disease, pharyngeal disease, history of traumatic brain injury and history of tumor, etc. History of drug applications such as atropine, scopolamine, belladonna, epinephrine, etc., which dilate the pupil, and organophosphorus poisoning, cervical sympathetic nerve palsy, and pontocerebral lesions, which narrow the pupil. Also, pay attention to the presence of ophthalmic dilatation or pupil reduction examinations or treatments. Pay attention to the neurological conditions such as headache, nausea, vomiting, cerebrovascular disease, brain tumors, facial sweating, and clarity of vision. Second, physical examination 1, general examination: pay attention to the body temperature, fever is mostly some infectious diseases such as cavernous sinus thrombosis, encephalitis, meningitis; eye protrusion is seen in cavernous sinus thrombosis, intraorbital tumor, carotid cavernous sinus fistula; eye murmur is seen in power artery cavernous sinus fistula; eye, neck or brain trauma; neck and pharynx with or without tumor, inflammation, enlarged lymph nodes, etc. 2. Pupils: are dilated or narrowed, are one side or both, direct and indirect light reflexes, eye fissure size, whether the eyeball is protruding, congested, whether the function of eye movement is affected, how is the visual acuity and visual field, whether there is diplopia, abnormal eye movement and convergence, etc., the same side of facial movement, sensation and sweating, whether there is optic papilla edema, congestion and atrophy in the fundus. Other neurological localization signs such as limb paresis, sensory abnormalities, abnormalities of vegetative nerve function, etc. 1. CT or MRI of brain or eye: check for brain tumor, inflammation, thrombosis, vascular malformation, brainstem lesion, medullary cavernous disease and orbital tumor, inflammation, etc. 2. MRI of the spinal cord: check for spinal cord cavitation, tumors, inflammation, etc. The above is the clinical manifestation and diagnosis of abnormal pupil symptoms. We hope that patients with ankylosing pupils will have a better understanding of the clinical manifestations and diagnosis of ankylosing pupil abnormalities. We hope that patients with ankylosing pupils will learn more about the clinical manifestations and diagnosis of ankylosing pupils, so that they can stay away from ankylosing pupil disease as soon as possible.