Acute plasma cell leukemia is a rare hematologic malignancy, a highly aggressive plasma cell malignancy that can be clinically classified as primary or secondary, with the latter occurring mostly in close association with multiple myeloma. There are no relevant studies to prove that the occurrence of acute plasma cell leukemia is associated with fracture in diabetic patients. The fractures in diabetic patients do not cause acute plasma cell leukemia, but clinical studies have shown that some patients with multiple myeloma can have combined diabetes, so diabetic patients with multiple myeloma in the course of disease progression have a chance to further induce secondary plasma cell leukemia.
The risk of fracture in diabetic patients is much higher than in the normal general population, and it is now believed that diabetic fractures are primarily associated with decreased bone density and impaired bone quality due to hyperglycemia. The risk of fracture in diabetic patients is higher than in the general population.