The preferred treatment for trigeminal neuralgia is oral medication, including a large class of drugs (carbamazepine, oxcarbazepine, baclofen, gabapentin, phenytoin sodium ……), all of which are indicated. With the administration of the drugs, patients can obtain satisfactory analgesia for several years. We should note that the principle of action of all these drugs is to reduce nerve excitability and suppress the patient’s pain sensation within 6 hours after taking the drug. However, the drugs cannot release the compression of the nerve by blood vessels and cannot change the development of the disease itself; therefore, at a later stage, the trigeminal nerve becomes more and more damaged by the pressure and the pain becomes more and more intense, and the drugs gradually fail. For patients whose medications fail, it is necessary to treat the cause of the disease. Trigeminal nerve microvascular decompression, which is now an internationally recognized standard of care. The procedure involves making a small incision in the hairline behind the ear, entering the skull to find the compressing vessel at the root of the trigeminal nerve, pulling the vessel away from the nerve, and then placing a soft cushion (Teflon spacer) between the nerve and the vessel, and the procedure is complete. The procedure was invented by P.J. Jannetta, an American, and has been performed worldwide for more than 40 years. The effectiveness of the procedure is over 90% and the safety has been well proven. Every year, more than 100,000 people worldwide are treated with this procedure. A large number of patients with trigeminal neuralgia who have failed to respond to medication are thus freed from pain and can start a new life.