Pharmacological liver injury transaminase 1200U/L, mainly because of drug-induced hepatocellular damage, need to stop the drug and hepatoprotective drug treatment, if the patient can not stop the drug need to actively carry out hepatoprotective treatment. Most of the drugs are mainly metabolized by the liver, but some drugs are more toxic and easy to cause liver damage, when the transaminase is 1200U/L, it is already very serious, we need to stop all the non-essential drugs, especially the drugs that are more damaging to the liver function, and apply a large number of liver-protecting drugs, such as glutathione, potassium and magnesium menthylate, etc. for liver-protecting treatment, and to promote the liver regeneration and metabolism. If the patient can not stop the drug due to the primary disease, at this time, it is recommended to actively carry out liver-protecting treatment, while taking compound glycyrrhizin tablets, silymarin, actively infusing diisopropylamine dichloroacetate, glutathione and other liver-protecting treatments. Patients must consult a physician before using medication to avoid self-selected drugs for treatment.