Diabetes mellitus blood sugar can not come down may be related to diet, lifestyle habits, medication and so on, you can consult the doctor to take targeted control of diet, reasonable exercise, adjust the medication and so on. 1. Diet control: Although the improvement of blood glucose level is related to hypoglycemic drugs, diet control is the basis of diabetes treatment and affects the effect of medication. Diabetic patients need to control the intake of sweets and eat more low glycemic index foods. 2. Reasonable exercise: After the diet is in place, it is also important to exercise in moderation. Reasonable exercise can consume calories, increase insulin sensitivity, and help control blood sugar. 3. Adjustment of medication: If the treatment program is unreasonable, the use of hypoglycemic drugs, insulin dose is not enough may lead to blood glucose can not come down, you can be under the guidance of the doctor, give metformin, pioglitazone and other drugs to increase insulin sensitivity, adjust the dose of insulin injection. It is recommended that diabetic patients whose blood glucose does not come down go to the endocrinology department of regular hospitals in time to improve the relevant examinations, and standardize the treatment under the guidance of the doctor, so as to avoid delaying the condition or leading to adverse reactions.