Folic acid tablets are best taken starting in the first trimester and continuing through the first trimester of pregnancy, usually at any time of the day. Folic acid is a B vitamin that promotes the maturation of young cells in the bone marrow. Folic acid deficiency can cause megaloblastic anemia as well as leukopenia, which is especially important for pregnant women. During pregnancy preparation, 400 μg of folic acid should be taken orally daily during the first trimester to prevent neural tube abnormalities, such as spina bifida and brain bulge, and to prevent or reduce the chance of congenital heart disease and cleft lip and palate in the fetus. Folic acid can be taken orally at any time of the day without affecting its absorption. If early pregnancy reactions are evident, it is not advisable to take it immediately to avoid nausea and vomiting. In addition, women need to pay attention to a nutritious diet during pregnancy preparation, eating less spicy, cold and stimulating foods and more fruits and vegetables. At the same time, folic acid should be taken under the guidance of a doctor and should not be increased or stopped blindly.