Folic acid tablets need to be taken from the first trimester and continued through the first trimester of pregnancy. They can usually be taken orally at any time of the day, depending on the individual. Folic acid is a water-soluble vitamin that is absorbed mainly in the small intestine and improves the quality of sperm and eggs and promotes embryonic development. Folic acid also promotes the production of red blood cells in the body and prevents the occurrence of anemia. Proper administration of folic acid can effectively prevent neural tube abnormalities, such as spina bifida and brain bulge, as well as prevent or reduce the chance of congenital heart disease and cleft lip and palate in the fetus. Folic acid can be taken orally at any time of the day and its absorption is usually not affected. Folic acid should not be taken on an empty stomach if the patient experiences nausea or vomiting when taking folic acid orally. If the early pregnancy reaction is more obvious in the morning, you can choose to take it at noon or in the evening to avoid nausea and vomiting. In addition, folic acid tablets can also be added to the diet and taken together, which can avoid adverse reactions and does not affect absorption.