There is no optimal time of day to take folic acid tablets, they can be taken at any time of the day, and for those with poor gastrointestinal function, it is recommended to take them one hour after meals. Folic acid is a water-soluble vitamin, which is mainly absorbed in the duodenum and upper jejunum, and can be absorbed and utilized normally when taken at any time of the day. However, since folic acid has a certain stimulating effect on the gastrointestinal tract, people with poor gastrointestinal function are prone to nausea and vomiting when taking folic acid, therefore, it is recommended to take it one hour after meals to reduce the symptoms. Women preparing for pregnancy and early pregnancy need to take folic acid every day to prevent fetal cleft lip and neural tube malformation. Besides, you can supplement folic acid in your daily life by eating foods that contain more folic acid such as spinach, beans and eggs, and you need to be careful to avoid drinking alcohol when taking folic acid tablets.