The methods of diabetes reversal generally include the following 5 aspects, i.e. management of pre-diabetes, weight loss, intensive glucose lowering, metabolic surgery, and pancreas or islet transplantation. 1. Management of pre-diabetes: pre-diabetes is the best time to reverse diabetes, in the pre-diabetes stage through diet and exercise therapy and other interventions can achieve the effect of weight loss, to promote the transformation of pre-diabetes to normal glucose metabolism; if the effect of lifestyle is not good, you also need to add medication, such as pioglitazone and so on. 2. Weight reduction: do a good job of weight management, scientific weight reduction. 3. Intensive hypoglycemia: mainly hypoglycemic drug therapy, especially insulin. Short-term insulin intensive glucose-lowering treatment can be used. 4. Metabolic surgery: it can affect food intake, digestion and absorption, and can cause changes in gastrointestinal hormones and/or intestinal flora to achieve weight loss and improve the efficacy of metabolic abnormalities, and ultimately reverse type 2 diabetes. 5. Pancreas or islet transplantation: Pancreas transplantation or islet transplantation is mainly used for the treatment of type 1 diabetes mellitus, especially for patients with end-stage renal disease. It should be noted that not all diabetes mellitus can be reversed, and after the reversal of diabetes mellitus still need to be regularly reviewed, if the diagnosis of diabetes mellitus, it is recommended to be actively treated under the guidance of the doctor.