Thyroglobulin is a glycoprotein secreted by the body’s thyroid cells and is one of the indicators of thyroid pathology. The normal value of thyroglobulin is usually 5-40 μg/L. If thyroglobulin is significantly lower, it suggests that the body has congenital thyroid underdevelopment, iodine deficiency or after thyroid surgery. It may cause hypothyroidism and symptoms such as pallor, false swelling of eyelids and face, indifferent expression, dry and rough skin and hair loss, which bring certain harm to the human body. Therefore, the lower the thyroglobulin, the better. The results of thyroglobulin tests, whether significantly higher or lower, indicate the presence of a possible disease in the body and should be taken seriously. To sum up, once you have a low thyroglobulin, you should seek medical attention in a timely manner, combining thyroid hormones, thyroid ultrasound and a series of other auxiliary tests to further understand the cause of the lower thyroglobulin and to carry out corresponding medication or other treatments.