Embryonic abortion is a condition in which the development of the embryo stops in the early stages of pregnancy for one reason or another, and the ultrasound examination shows an irregular gestational bursa or fetal morphology with no fetal heartbeat, or a withered gestational bursa. The clinical category is miscarriage or stillbirth. There are many reasons for embryonic abortion. Endocrine disorders During the early development of the embryo, three important hormone levels are needed, one is estrogen, one is progesterone and one is human chorionic gonadotropin, as the mother, her own endogenous hormones are not enough to meet the needs of the embryo, which may cause embryonic abortion and miscarriage. Luteal insufficiency can cause delayed endometrial development and short luteal phase, which can affect the implantation of fertilized eggs or early pregnancy miscarriage. Luteal insufficiency is often accompanied by other glandular function abnormalities, such as hyper- or hypothyroidism, diabetes, androgenism and hyperprolactinemia, etc. These factors are not conducive to embryonic development and are closely related to miscarriage. Second, immune factors Common autoimmune diseases are systemic lupus erythematosus, scleroderma, mixed connective tissue disease, dermatomyositis, etc. The second is the problem of reproductive immunity. If we carry certain antibodies ourselves, it may affect the development of the embryo. In fact, the detection of antibodies is not the same in every hospital, and the doctors’ opinions are not the same. From the perspective of our research, we believe that there are four factors that affect the development of the embryo. The fourth is the anti-chorionic gonadotropin antibody, which is an important hormone that is secreted seven days after the union of sperm and egg, but if you have this antibody, it will resist the secretion of the hormone and may cause the embryo to stop. Third, the uterus is abnormal. The internal environment is the endometrium, if it is too thin or too thick, it will affect the implantation. Miscarriages caused by uterine defects account for about 10% to 15%, and the common ones are: 1. Congenital abnormalities of Mullerian ducts include unicornuate uterus, double uterus and bicornuate uterus resulting in narrow uterine cavity and restricted blood supply. Abnormal development of uterine arteries can lead to asynchronous molting and abnormal implantation; 2. Uterine adhesions, mainly caused by uterine cavity trauma, infection or residual placental tissue after causing uterine cavity adhesions and fibrosis. This prevents normal molting and placental implantation; 3. Decreased blood supply due to uterine fibroids and endometriosis leads to ischemia and venous dilatation, unsynchronized molting, abnormal implantation and hormonal changes caused by fibroids can also cause pregnancy failure; 4. Congenital or injurious endocervical laxity and abnormal cervical development due to intrauterine treatment with ethylene estradiol often lead to miscarriage in mid-term pregnancy. Chromosomal abnormalities can also lead to early miscarriage due to embryonic failure. Chromosomal abnormalities include quantitative and structural abnormalities. quantitative abnormalities can be divided into aneuploidy and polyploidy, the most common abnormal karyotype is triploidy, and trisomy 16 accounts for 1/3, which is often lethal. 25-67% of trisomy 21, 4-150% of trisomy 13, and 6-33% of trisomy 18 are bound to miscarriage. Others are haploid (4SX) and tetraploid due to abnormal oogenesis resulting in embryonic failure. Structural abnormalities include deletions, balanced translocations, inversions, overlaps and other closures. Balanced translocations are the most common chromosomal abnormalities. Current research on chromosomal problems suggests that chromosomes pair, interchange and separate to form gametes, and gametes combine to form conjoined gametes. If there is an abnormality in one of the congeners, it results in failure to develop normally and can lead to miscarriage, stillbirth, stillbirth, and malformed children; therefore, prenatal diagnosis is required to prevent the birth of chromosomally affected children. There is no effective treatment for miscarriage and fetal abortion caused by carrying chromosomal abnormalities in Western medicine, and only prenatal genetic counseling and diagnosis can be performed. For chromosomal abnormalities, theoretically there is a chance of delivering normal karyotype and carrier babies, and prenatal diagnosis is done for these couples to ensure the birth of normal babies. Of course, current research has also shown that both couples have normal chromosomes, but chromosomal abnormalities occur during gamete formation and embryo development. For example, if a woman is older than 35 years old and her eggs are aging, she is prone to chromosomal non-separation, resulting in chromosomal abnormalities; abnormal semen, such as large-headed malformed sperm that are mostly diploid and form polyploid embryos after fertilization leading to miscarriage. The influence of adverse environment such as toxic chemicals, radiation, high temperature, etc. can also cause chromosomal abnormalities in embryos. Therefore, the key to prevent chromosomal abnormalities leading to fetal abortion is to regulate the health of both spouses so that the functions of the internal organs are normally coordinated, the yin and yang are balanced, the best pregnancy is selected, and the adverse environment is kept away. V. Reproductive tract infections In addition to the above factors, early pregnancy miscarriage due to infection is receiving more and more attention from scholars at home and abroad. Severe TORCH infection in early pregnancy can cause embryonic death or miscarriage, while milder infections can also cause embryonic malformation. Studies have shown that cytomegalovirus can cause premature abortion and intrauterine fetal death. After maternal infection, the pathogens can travel to the placenta through the bloodstream, causing damage to the chorionic villus and capillary endothelium, and destroying the placental barrier, resulting in miscarriage, embryonic arrest and fetal malformation. In recent years, many studies have shown that mycoplasma infection is associated with embryonic arrest, and the positive rate of cervical secretion mycoplasma infection in women with embryonic arrest is significantly higher than that in normal women, and there is a highly significant difference. Environmental factors The change in physiological state during pregnancy has caused large changes in the absorption, distribution and excretion of therapeutic drugs and various environmental harmful substances in the mother’s body. Many drugs and environmental factors are important factors in causing early embryonic death or fetal malformations. Environmental hormones can act directly on the central neuroendocrine regulatory system, causing disruption of reproductive hormone secretion, decreased fertility and abnormal embryonic development. There are various environmental factors that cause miscarriage, including physical factors such as X-rays, microwaves, noise, ultrasound, high temperature, and heavy metals such as aluminum, lead, mercury, and zinc that affect the fertilized egg’s implantation or directly damage the embryo and cause miscarriage. Various chemical drugs such as dichlorohydrin, carbon disulfide, anesthetic gases, oral antidiabetic drugs, etc. can interfere with and impair reproductive function, causing embryo miscarriage, stillbirth, malformation, developmental delay and functional disorders. The early embryonic development can be affected by bad habits such as smoking, alcoholism, coffee, and certain drugs.