The process of human pregnancy is like the planting of seeds in the spring, nurturing, germination, growth and harvest in the fall, which is a long, complex and wonderful process, which is also affected by many factors, such as the quality of the seeds themselves, the environment of the soil, the absorption of nutrients, the sunshine, the rain, and the attack of pests and diseases, etc. If the egg does not grow well after early fertilization, or does not germinate well, or stops growing after germination, we call it “embryonic arrest”. If the egg does not grow well after early fertilization, or does not germinate well, or stops growing after germination, we call it “embryonic arrest”. Some common reasons are as follows: 1, the health of the sperm father: the chromosomes in the sperm bear the important responsibility of passing on the genetic code of the sperm father, which will be passed on to the next generation of the sperm father during the sperm-egg union process, that is, “you reap what you sow, and you reap what you sow”. If the genetic code of the father of the sperm is passed on incorrectly, malformed or immature, the embryo will not be able to develop into a healthy fetus. Polluted environment and food, harmful substances, excessive radiation, unhealthy lifestyle, infections, etc. can all harm the health of the father and cause embryo sterilizations. 2. Abnormalities in the genetic code of the embryo: About 50-60% of embryos stop developing because of problems with their own genetic code, such as more, less, or interrupted code, or rearrangement of seats in the code, etc., which may affect the correct transmission of the genetic code of the spermatozoa parents, resulting in the failure of the embryo to develop. Environmental reasons: Whistling under the dome, excessive arsenic, lead, benzene, formaldehyde, radiation, noise and high temperature can all affect the development of the embryo. Tobacco, alcohol, drugs, certain medicines, diseases and so on can directly or indirectly harm the embryo. (1) Systemic diseases of pregnant mother: Herpes simplex virus, cytomegalovirus, toxoplasmosis and other infections may enter into the blood of embryo through the placenta and cause his death. Severe anemia, severe heart disease, nephritis, high blood pressure, diabetes can also lead to hypoxic arrest of the embryo. If high fever occurs after bacterial or viral infection, body temperature reaches 38.5℃ or above, it will affect the embryo’s brain development. (2) Poor environment inside and outside the uterus: The embryo has to stay in the uterus for more than 9 months before it can be born healthy. Therefore, the environment of the uterus is also very important to the healthy growth of the embryo. 10%-15% of the embryo’s failure to develop is caused by poor uterine structure and environment, such as serious abnormalities of the uterine structure, uterine deformities, congenital dysplasia, uterine fibroids and so on. Adhesions in the uterine cavity and scarring of the intrauterine soil caused by repeated scraping operations further affect the implantation and growth of the embryo after fertilization. If the embryo grows in the vicinity of the endometrium with little blood supply and scarring and fibrosis, the embryo will be like “planting crops in the cracks of the stone”, which is also a problem for our obstetricians and gynecologists all over the world. (3) Endocrine disorders of the pregnant mother: The fertilization of the eggs and the development of the baby depends on the close cooperation of each molecule in the complex and fine endocrine regulatory network of the pregnant mother, each in its own way, but also to accept the unified scheduling, and none of the links can be out of order. The three major hormones: estrogen (estradiol), progesterone (progesterone) and human chorionic gonadotropin (HCG) are the main support for the early development of the embryo. If the embryo does not receive favorable support from the three major hormones, life will not continue. However, the three major hormones alone cannot completely determine the dryness of the embryo. Other hormones secreted by the mother’s hypothalamus, pituitary gland, thyroid gland, pancreas and ovaries also play an important role in determining the fate of the embryo. This is why abnormal thyroid function, polycystic ovaries, high insulin, high androgens and high prolactin can also affect the development and survival of the embryo. (4) Infections of the mother: If the mother is infected by bacterial or viral infections such as cytomegalovirus, rubella virus, toxoplasmosis, etc. in the early stage of pregnancy, the placenta can be infected and the placental defense barrier can be destroyed. Pathogens can enter the embryo and cause fetal failure or developmental abnormalities. Recently, many studies have also found that cervical mycoplasma chlamydia infection or other pathogens such as gonococcus can also pass up the uterus to infect the intrauterine environment where the embryo grows, and then ultimately infect the embryo and cause it to leave. (5) The immune status of the mother and the embryo: About 40% of the embryos that stop developing are related to immune abnormalities in the mother’s body. Our body recognizes that “this is mine, I recognize it and accept it”. But the embryo itself is the fruit of love between the father and the mother: “It is half of the mother and half of the father”. If the embryo is not helped by the mother, the mother does not recognize the embryo that is “half of the father”: “He is not mine, I do not allow him to exist in my realm”. Therefore, the mother rejects him and expels him. But in most cases, why does the embryo grow peacefully inside the mother? This is due to the complex and specific immunological connection between the embryo and the mother, which is finely converged on the meconium of the placenta. Through this connection, the mother and the embryo recognize each other, talk to each other and adapt to each other. The embryo, which is half the father’s, is finally recognized by the mother, who gives it the right to grow and develop within her. The embryo gradually strengthens its position until it is born healthy. However, if the mother is still unable to accept the embryo for a number of reasons, the embryo will have to accept its fate. The main immunological reasons for this are the histocompatibility antigens of the father, the specific antigens of the embryo, the blood group antigens, the presence of sufficient antibodies in the mother’s body for the protection of the embryo – closed antibodies, etc., as well as the mother’s ability to regulate the immune system, and so on. Another type of immune abnormality that affects the development of the embryo is the problem of the mother herself. If the mother loses her memory and no longer recognizes her own things (self-antigens), or if there is a small change in her things that she does not recognize, then the mother’s body builds up an army of antibodies to protect the embryo. The pregnant mother’s body then assembles a fighting force to attack and neutralize these self-antigens (aka autoantibodies are produced). The autoantibodies combine with the self-antigens to form an antigen-antibody complex. Antigen-antibody complexes can stay in the interface or blood vessels between the mother and the embryo, affecting and interfering with their conversation, communication, and even the embryo’s nutritional intake from the mother, resulting in gradual malnutrition, hypoxia, and even premature death of the embryo. This is often the case when the mother has systemic lupus erythematosus, scleroderma, connective tissue diseases, dermatomyositis, etc., and especially when anticardiolipin antibodies are present. Other fertility-related immune antibodies, such as anti-sperm antibodies, anti-endometrial antibodies, and anti-chorionic gonadotropin antibodies, may also be associated with the development of the embryonic child to some extent, but many studies have concluded that this is not necessarily a necessary, causal link. (6) Coagulation status of the pregnant mother: After our body bleeds from an injury, the bleeding will also slowly stop. This is because our organism has its own clotting function to combat bleeding. In the vast majority of cases our body is in a good clotting balance. However, if this balance is not too good and the coagulation is strong, our body will be in a “pre-thrombotic state”. Normally the “pre-thrombotic state” does not affect our health and does not form emboli that block our blood vessels, but this is not the case for pregnant mothers. In the pre-thrombotic state, which has no effect on the general population, the body itself may already have many tiny blood clots, which may stay in the tiny capillaries of the pregnant mother’s embryo’s nutritional exchanges, causing blockage of the microvessels, and then infarcting the blood vessels of the placenta. The embryo can not get enough oxygen and nutrients from it, and the embryo will gradually die. The principle is just like the sewerage pipes (capillaries) that we use for a long time, the stagnant material deposited inside the pipes over time affects the flow of water and even causes stagnation. In order to correct this situation so that the embryo can continue to grow, the doctor must use anticoagulant drugs to unclog the microcirculation and restore the embryo’s nutrient absorption. After 10 weeks of pregnancy, the embryo finally grows into a fetus. If, unfortunately, the embryo does not make it through this stage, and if this is the only painful experience, there is no need for the mother to be overly anxious or worried. In most cases, it is because there is a serious problem with the embryo’s own genetic coding, and he is not fit to continue to live in this world. His departure is the result of the Creator’s eugenic selection, so there is no need to keep him, but of course, if you have the conditions, you can check the genetic code of the departed embryo. If it’s not a genetic coding problem, or the pregnant mom has already had more than 2 – 3 embryo stops, then it’s time to do a systematic checkup, including the sperm father and the pregnant mom. Find the cause, better correct it and try again, eventually 70 – 80% will end up better. For a variety of reasons, there are also misconceptions about settling for a baby that are difficult to correct these days: the idea that as soon as you get pregnant, you start checking for progesterone, and you start taking progesterone and progesterone shots. This often doesn’t address the root cause, but is just a comforting consolation with progesterone. Lastly, we also ask that expectant mothers and fathers understand that reproductive research has not yet fully clarified the mysteries of human fertility. Until now, according to the highest level of medical technology on earth, there are still about 20%-30% of embryonic embryos that are unable to stop reproducing for reasons that cannot be clearly identified, or what doctors usually call “unknown reasons”, which are like icebergs sinking in the sea water and need to be further explored.