The drugs used to treat diabetes are: sulfonylureas, glipizide, biguanides, glitazones, insulin and so on. 1. Sulfonylureas: such as glipizide, gliclazide, etc., are mainly used for newly diagnosed type 2 diabetes mellitus in non-obese patients; they should not be used for children, pregnant women, major surgeries, and patients who have serious adverse reactions to drugs. 2. Glargine: commonly used drugs include Repaglinide and Naglinide, which are applicable to the early postprandial hyperglycemic stage of type 2 diabetes mellitus; this kind of drugs may show hypoglycemia or weight gain. 3. Metformin: the most widely used drug in clinic is metformin, as the treatment of type 2 diabetes mellitus, it can be used alone or in combination with other hypoglycemic drugs; however, this kind of drug may have adverse symptoms such as skin allergy, vitamin B12 deficiency and gastrointestinal reaction. 4. Glitazones: such as rosiglitazone and pioglitazone, mainly used in patients with type 2 diabetes mellitus, especially with obesity or insulin resistance is obvious; some patients taking this drug, there can be weight gain, edema and other adverse reactions; pregnant women, lactating mothers, heart failure, and active liver disease patients are prohibited to take. 5. Insulin: Insulin is suitable for type 1 diabetes, type 2 diabetes or some special types of diabetes, etc.; however, subcutaneous injection of insulin may cause allergic reactions, such as itching at the injection site or urticaria-like rash. After patients clearly have diabetes and distinguish which type it is, they need to apply medication under the guidance of the doctor, and must not use medication without authorization, so as not to cause adverse reactions.