Dapoxetine and sertraline are medications for different diseases and cannot be compared, so there is no such thing as which medication is better, it is recommended to choose the right medication according to the different diseases and follow the doctor’s instructions. 1. Dapoxetine can treat premature ejaculation and poor ejaculation control, and its adaptive population is 18 to 64 years old male patients, by prolonging the time of ejaculation and play a role. Adverse reactions such as nausea, headache, insomnia, and dizziness may occur after administration. Dapoxetine hydrochloride is associated with a significant increase in blood levels when combined with potent cytochrome P450 3A4 inhibitors. In addition, it can interact with drugs such as thioridazine and monoamine oxidase inhibitors. Therefore, this drug should not be combined with thioridazine, monoamine oxidase inhibitors, and potent cytochrome P450 3A4 inhibitors. It is contraindicated in the following conditions: severe renal impairment; moderate to severe hepatic impairment; hypersensitivity to the drug. Sertraline should be used with caution in patients with mild to moderate renal impairment. 2. Sertraline inhibits the reuptake of 5-hydroxytryptamine by central neurons and is used for the treatment of symptoms associated with depression. Adverse reactions such as insomnia, nausea, dizziness, and ejaculatory disorders may occur after use of the drug. Patients at high risk for drug use should be monitored appropriately. The drug can interact with monoamine oxidase inhibitors such as silagiline and other drugs such as pimozide when combined. It is contraindicated in persons who are allergic to the drug; in persons who are taking monoamine oxidase inhibitors; and in persons who are taking pimozide. If you need to use the above drugs, please under the guidance of a doctor, strictly follow the doctor’s instructions to take medication, do not self-medication.