Tamsulosin-induced postural hypotension is treated with prophylaxis and, if necessary, medication. Commonly used medications include midodrine and fludrocortisone. 1. Midodrine Indications: The drug acts selectively on adrenergic α-receptors, which can constrict peripheral small blood vessels, and has been proved to have the effect of significantly improving patients’ upright blood pressure and upright tolerance. ADVERSE REACTIONS: Adverse reactions such as abnormal scalp sensation and pruritus, chills, urinary incontinence, urinary retention, and urinary frequency may occur. Contraindications: The drug is contraindicated when suffering from severe organic heart disease, acute kidney disease, pheochromocytoma, hyperthyroidism, and persistent recumbent hypertension. Pregnant lactating women need to use the drug with caution. 2. Fludrocortisone Indications: the essence of salt corticosteroid, can reduce salt loss, expand blood volume, and increase the sensitivity of blood vessels to adrenal receptors, so as to achieve the effect of elevated blood pressure, can be applied to the elderly postural hypotension. Adverse reactions: Edema, hypertension, potassium abnormalities and other adverse reactions may occur with the use of this drug. Contraindications: the drug is contraindicated in drug allergy; caution is recommended in pregnant women, presence of hepatic impairment, unexplained mucous edema and other conditions. It should be noted that the treatment of postural hypotension is mainly preventive, it is recommended to avoid standing for a long time, for people with poor venous return can consider wearing compression stockings. Repeated episodes of postural hypotension require discontinuation of tamsulosin or adjustment of medication under the direction of a clinician. The above medications should be used under the supervision of a physician.