The claim that Ganoderma lucidum is the “nemesis of diabetes” has no scientific basis and is not true. Diabetes is a chronic metabolic disease that requires a combination of diet, exercise and medication for long-term standardized treatment and regular monitoring to delay the onset of complications. Ganoderma lucidum belongs to traditional Chinese medicine, which has the effects of regulating metabolism, detoxifying and protecting the liver, and calming and tranquilizing the mind, but it can’t prevent or treat diabetes. There is no evidence that Ganoderma lucidum can prevent and treat diabetes, so the claim that Ganoderma lucidum is the “nemesis of diabetes” is not true. Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose, and requires a combination of dietary therapy, exercise therapy and medication. Low-sugar, low-fat diet, appropriate exercise, with hypoglycemic drugs, such as metformin, etc., according to the condition of the choice of suitable drug therapy. Diagnosed with diabetes, should be standardized treatment under the guidance of the doctor, do not trust the prescription, delay the condition.