Stage IV sigmoid colon cancer belongs to advanced colon cancer, and the treatment of patients is mainly based on drug therapy, and the drugs available include chemotherapy drugs, targeted therapy drugs, immunotherapy drugs and symptomatic drugs. 1. At present, oxaliplatin, irinotecan and fluorouracil are commonly used as chemotherapeutic drugs, and two or three kinds of chemotherapeutic drugs can be used in combination according to the patient’s physical condition. 2. Before the use of targeted drugs, it is necessary to first test the patient’s kras gene status, according to the test results of the choice of drugs, kras gene mutation, the choice of targeted drugs bevacizumab, kras gene wild-type, the choice of targeted drugs cetuximab. 3. Before using immune drugs, it is necessary to test the immunity expression of patients. For patients with stage IV sigmoid colon cancer with high expression of microsatellite unstable immunity, they should choose anti-tumor treatment with immune drugs such as nabulizumab and pembrolizumab. 4. Symptomatic treatment drugs mainly refer to the drugs to reduce pain, or abdominal distension and other symptoms, such as morphine, oxycodone extended-release tablets and other analgesic drugs.