Oral ulcers are one of the most common manifestations of oral mucosal diseases, and the causative factors are more complex, related to micronutrient deficiency, digestive system diseases, local trauma, and infection. Clinically, medications are more effective in treating oral ulcers, but they are not limited to five kinds. In addition to oral drugs, local application of film, gel, spray, etc. are also more common: 1, watermelon cream: the spray is more widely used, has the effect of clearing heat and fire, activating blood stasis, anti-inflammatory and pain relief, can promote the growth of oral epithelial cells, accelerate the healing of ulcer wounds; 2, cidium iodine tablets: can kill a variety of pathogenic microorganisms in the oral cavity, reduce swelling and pain, and promote the healing of oral mucosa, the oral ulcer 3.Luxin pill: Chinese medicine preparation, can be taken orally or grinded into powder and applied to the affected area, with the effect of clearing heat, diarrhea, generate fluid and blood, can improve the symptoms; 4.Bingboran: the main ingredients are ice chips, borax, cinnabar, etc., can be dipped into the appropriate amount of cotton swabs and put on the ulcer, with the effect of clearing heat and detoxifying, dispel decay and muscle, can generally be healed within a few days; 5.Vitamin preparations: supplement Vitamin C, vitamin B are beneficial to the relief of mouth ulcers, vitamin C can promote collagen and intercellular synthesis, vitamin C tablets grinded and applied to the affected area can improve the symptoms; vitamin B complex also has a certain therapeutic effect on mouth ulcers. In addition to the above five drugs, hormone preparations such as prednisone and dexamethasone film, as well as cimetidine, erythromycin, compound borax solution, compound chamomile lidocaine gel, oral ulcer dispersion, recombinant human epidermal growth factor gel and other drugs are also effective in the treatment of oral ulcers. In addition, if the cause of the disease can be clarified, it can better help to treat mouth ulcers and reduce recurrence.