”Plasmacytoid mastitis is a disease that occurs during the non-lactating period and is distinctly different from lactating mastitis. The cause of this disease is not fully understood, but is not due to bacterial infection. It is mainly due to the accumulation and overflow of fatty material in the ducts, which causes chemical irritation and immune reaction around the ducts, resulting in a large number of plasma cells infiltrating the ducts, hence the name plasma cell mastitis. Repeated attacks and fistulas are formed after rupture, which can be followed by bacterial infections that do not heal for a long time. So it is a special kind of inflammation of the breast. Plasma breast is a benign lesion and patients should not be too alarmed. The disease is related to nipple dysplasia, like nipple invagination and nipple splitting, etc. Due to the complex and variable pathological features, there are various names, such as “acne-like mastitis”, “ductal dilatation of the breast”, “chronic mastitis “chronic mastitis”, etc. Plasma milk can reappear after cure when resistance is low such as exertion and cold. Plasma breast manifestations: sudden onset and rapid development. The patient feels localized pain and discomfort in the breast, and a lump can be palpated. The lump is located under the areola or extends to a certain quadrant. The mass is hard and tough. The surface is nodular, with poorly defined borders and no adhesions to the chest wall. The skin of some breasts is edematous and orange peel-like, and there are usually no systemic symptoms such as fever. The nipples are often edematous and orange peel-like, usually without fever and other systemic symptoms. The nipples often secrete powder-like material with a foul odor. A small number of patients have nipple discharge, which is bloody or watery, and may be accompanied by enlargement of the axillary lymph nodes on the affected side. In the late stage, the lump becomes softened and forms an abscess. When the abscess breaks down, pus mixed with powder-like pus flows out and causes fistulas in the areola, resulting in recurrent wounds and scarring, making the nipple sunken into a concave. This disease is not treated with antibiotics alone, so Chinese herbal medicine together with surgery (mastectomy is feasible) is the main treatment. In our department, Chinese herbal medicine is very effective in treating plasma breast. Mild plasma breast can be cured by using Chinese herbal medicine only, and severe patients can be treated with Chinese herbal medicine in the perioperative period to reduce the scope of surgery, maintain the shape of the breast, and reduce the physical and mental pain and economic burden of patients. Both pulpy breast and granulomatous mastitis are difficult diseases of the breast, which are benign diseases with malignant behavior. For nipple invagination to be timely manipulation reset and timely removal of secretions in the milk ducts can play a preventive role.