High risk factors for the development of endometrial polyps and treatment

Endometrial polyps are the result of localized endometrial overgrowth, consisting of glands, mesenchyme and blood vessels. Polyps can be of different sizes, multiple or single, with or without a tip. Ageing, hypertension, obesity, diabetes, perimenopausal and postmenopausal hormone replacement therapy, and long-term tamoxifen application after breast cancer surgery are not only high risk factors for endometrial polyps, but also for atypical hyperplasia and malignant transformation of endometrial polyps. The malignant rate of endometrial polyps is not high 0-12.9%, and endometrial polyps can be found in 10-40% of abnormal premenopausal uterine bleeding. However, the malignancy rate is not high, but the chance of malignant endometrial polyps increases with age, especially in postmenopausal patients with irregular vaginal bleeding. In addition there is endometriosis, adenomyosis is also a good factor in the formation of endometrial polyps.  If these high-risk factors for endometrial polyp formation continue to exist, even if hysteroscopic surgery is performed, there is still a risk of recurrence after surgery, with a postoperative recurrence rate of 2.5%-3.7%. To avoid recurrence of endometrial polyps, patients without fertility requirements, abnormal menstruation and heavy menstrual flow can choose to use progestin-containing contraceptive ring—Manuel IUD. After the IUD, progestin inhibits endometrial proliferation and the recurrence rate of endometrial polyps may decrease. Oral contraceptives and progestins also have an inhibitory effect on the development of endometrial polyps. Total hysterectomy for endometrial polyps in postmenopausal symptomatic women is a radical treatment without the possibility of polyp recurrence and malignant transformation, but it is a more invasive procedure and is not recommended in the absence of atypical endometrial hyperplasia hyperplasia.  Conservative treatment of endometrial polyps 25%-27% of endometrial polyps can regress on their own within a year, especially if they are less than 25px in diameter. The role of medication is limited. The application of GNRHa before hysteroscopy can thin the endometrium, stop the bleeding and facilitate the surgery, but it will recur if the medication is stopped, and the medication is expensive and has side effects. Therefore, drug treatment of endometrial polyps is not recommended at present. Small asymptomatic polyps after menopause are unlikely to become malignant and can be selected for observation.