Vitiligo is a pigment loss skin disease related to the body’s immune function, it occurs in many places, head and face, neck, trunk, limbs can occur, lips are also present. Because the lips are richer in blood and heavier in color, the clinical manifestations of vitiligo occurring on the mouth are not particularly very obvious compared to other normal skin. In terms of medication, topical tacrolimus ointment can be used topically for anti-inflammatory and immunity regulating treatment, twice a day for long-term use, and there are no local side effects. The lips are not recommended to use irritating drops, and can be treated with tincture of bone marrow. If possible, you can also take oral medication to regulate the immune system and pay attention to your own rest.