The symptoms of facial muscle spasm are involuntary twitching of the face, with the initial onset of “eyelid jumping” and then involving the ipsilateral corners of the mouth and the entire face. The onset is usually on one side of the face, and the onset is mostly in middle-aged and elderly people, mostly after the age of 40. The facial twitching can be aggravated by exertion and mood swings, and the course of the disease can be prolonged, bringing impact on the patient’s life. For the clinical treatment of facial spasm, the conventional method is to take drugs, so what drugs can facial spasm take to stop twitching or relieve twitching, the following is a detailed introduction to the common drugs for the treatment of facial spasm. Carbamazepine: clinical treatment is the drug of choice, start with 0.1g once, 2 times a day; after the second day, increase 0.1~0.2g every other day until pain relief, maintenance amount 0.4~0.8g daily, divided into doses; the maximum amount should not exceed 1.2g daily. after pain relief then reduce the dose maintenance, maintenance time should be more than 6 months. Oxcarbazepine: The starting dose is 300mg/d, and the dose can be gradually increased to 900~3000mg/d to achieve satisfactory efficacy. Phenytoin sodium: It has certain efficacy in face muscle spasm, but the efficacy is not as reliable as carbamazepine, so it is not preferred. Phenytoin sodium tablets drug side effects, the recommended starting dose is 100 mg twice daily, which can be increased to 300-400 mg within 2-3 weeks. If there is no pain relief the drug should be discontinued and if relief is achieved the dose is gradually reduced to maintain over 6 months. Methylcobalamin: 1500μg, orally, usually 1 tablet once, 3 times a day for adults, usually used in combination with the above three drugs. All of the above are common drugs for the current clinical treatment of facial spasm. According to the etiology of facial spasm, most patients have facial twitching due to compression of the facial nerve by tortuous intracranial vessels. Therefore, the drugs can relieve the twitching, but cannot cure the facial spasm. In addition, facial muscle spasm medication process, patients need to pay attention to dietary care, life rules, etc., can not stay up late, avoid eating high heat, too cold, spicy stimulating, hard food. The day is cold, pay attention to body warmth, especially the face. If medication cannot relieve twitching and twitching episodes are still frequent, surgical treatment should be considered. For facial twitching caused by vascular compression factors, microvascular decompression surgery can be used to achieve a cure. Microvascular decompression is the application of microsurgical techniques to remove the responsible blood vessels and nerves, and implant decompression materials in both to achieve the disappearance of facial twitching. This procedure does not damage the nerves and is able to preserve the integrity and functionality of the facial nerves, and has become the surgical method of choice for the treatment of facial tics, trigeminal neuralgia, glossopharyngeal neuralgia, and other cerebral neurological disorders.