The medical clinic found that some men have normal sperm strength and density, but lack the same vital substance, acrosome enzyme, which makes it difficult for their wives to conceive. Acrosomal enzyme is located in the inner membrane of the sperm acrosome and the equatorial membrane, it is an indispensable neutral protein hydrolase in the process of fertilization. Acrosomal enzyme can hydrolyze the egg zona pellucida glycoprotein, which allows the sperm to cross the egg mound and then the zona pellucida, allowing the sperm to fuse with the egg; it also promotes the release of kinins in the reproductive tract, thus enhancing the vitality of the sperm and promoting the movement of the sperm. Acrosomal enzyme is a substance released by the spermatozoa during the encounter with the egg, which dissolves the radial crown and zona pellucida at the periphery of the egg. With the help of this enzyme, the sperm can cross the impenetrable zone outside the egg and “meet” the egg to form a fertilized egg in the fallopian tube. It is then that a new life is announced. Without acrosomal enzymes, the sperm cannot penetrate the zona pellucida of the egg, which is like an iron barrier that cannot be crossed, and naturally, fertilization cannot be achieved. The purpose of fertilization cannot be achieved. There are more and more cases of male acrosome enzyme deficiency, and many infertile couples are often found to have normal reproductive systems on both sides during multiple examinations, only to find out that it is acrosome enzyme deficiency when they are further examined carefully. There are many causes of acrosome enzyme deficiency, such as changes in living environment, food pollution, excessive mental stress, excessive use of electrical appliances, and frequent late nights. Therefore, men should pay attention to dietary hygiene, strengthen exercise, walk outdoors often, and relax while working hard. Men with acrosomal enzyme deficiency are advised to take some herbal medicines that strengthen the spleen and kidneys, invigorate blood circulation and remove blood stasis, and to adhere to long-term treatment so that the acrosomal enzyme index can gradually return to a normal state so that the wife can get pregnant.