The main causative factor is the pathogenic infection of the prostate. It is caused by the infection of the prostate by virulent bacteria or other pathogens with low body resistance and rapid growth and multiplication, mostly bloodstream infection, retrograde infection via the urethra. The main pathogen is Escherichia coli, followed by Staphylococcus aureus, Klebsiella pneumoniae, Aspergillus, Pseudomonas, etc. The majority of these are single pathogen infections. The main pathogenic factors are also pathogenic infections, but the body is more resistant or/and pathogens are less virulent, mainly retrograde infections, the pathogens are mainly Staphylococcus spp, followed by Escherichia coli, Corynebacterium spp and Enterococcus spp. Prostate stones and urinary reflux may be important reasons for the persistence of pathogens and recurrence of infection. The etiology is complex and widely debated: it may be caused by a single initiating factor, or it may be multifactorial from the beginning, with one or more playing a key role and interacting with each other; or it may be a number of different diseases that are difficult to identify but have the same or similar clinical manifestations; or even these diseases may have been cured and the damage and pathological changes caused by them still continue to act independently. Most scholars believe that the main etiology may be the result of a combination of pathogenic infection, inflammation and abnormal pelvic floor neuromuscular activity and immune abnormalities. 1. Pathogenic infections In this type of patient, although routine bacterial examination fails to isolate the pathogen, it may still be associated with some specific pathogens: such as anaerobic bacteria, L-type Aspergillus, nanobacteria, or Chlamydia trachomatis, mycoplasma and other infections. It is also possible to detect up to 77% of local prokaryotic DNA in this type of patient; some clinical “aseptic” prostatitis with chronic inflammation, recurrent or aggravated, may be related to these pathogens. Many patients with prostatitis have a variety of urodynamic changes, such as reduced urinary flow rate, functional urinary tract obstruction, and dysfunctional forced urinary muscle-urethral sphincter synergy. These functional abnormalities may only be a clinical phenomenon, and their nature may be related to various underlying pathogenic factors. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. These changes in mental and psychological factors can cause plant nerve dysfunction, resulting in posterior urethral neuromuscular dysfunction, leading to pain in the pelvic region and dysfunctional urination; or cause changes in the function of the hypothalamic-pituitary-gonadal axis and affect sexual function, further aggravating the symptoms, and eliminating mental tension can lead to symptom relief or healing. However, it is not clear whether the psychosomatic changes are the direct cause or secondary manifestations. 4, neuroendocrine factors Prostate pain patients are often prone to fluctuations in heart rate and blood pressure, indicating that it may be related to the autonomic response. Their pain has the characteristics of visceral organ pain. Local pathological stimulation of the prostate and urethra triggers spinal reflexes through the afferent nerves of the prostate, activates astrocytes in the lumbar and sacral medulla, nerve impulses send out impulses through the genitofemoral nerve and the ilioinguinal nerve, and sympathetic nerve endings release norepinephrine, prostaglandins, calcitonin gene-related peptides, substance P, etc., causing vesicourethral dysfunction, and This leads to abnormal activity of the perineum and pelvic floor muscles and persistent pain and involvement pain in the corresponding areas other than the prostate. The immune response is abnormal. Recent studies have shown that immune factors play a very important role in the development and course of type III prostatitis, and changes in the levels of certain cytokines, such as IL-2, IL-6, IL-8, IL-10, TNF-α and MCP-1, can occur in the prostatic fluid and/or seminal plasma and/or tissues and/or blood of patients, and IL-10 levels are similar to those of patients with type III prostatitis. The level of IL-10 is positively correlated with the pain symptoms of patients with type III prostatitis, and the application of immunosuppressive therapy has a certain effect. 6, oxidative stress theory Under normal circumstances, the body’s oxygen free radical production, utilization and removal in a dynamic balance. Prostatitis patients with excessive production of oxygen free radicals or/and the role of the free radical scavenging system is relatively reduced, thereby reducing the body’s ability to respond to oxidative stress, oxidative stress products or/and by-products increase, may also be one of the pathogenesis. The actual fact that there is no clinical symptoms, and that it is often detected during the examination of other related diseases, there is a lack of research data on the pathogenesis of the disease, which may be the same as some of the causes and pathogenesis of type III prostatitis.