Once the onset of severe pancreatitis occurs, active management must be carried out within 72 hours of onset (from abdominal pain to hospital admission), and the goals to be achieved within these golden 72 hours include the following. In the case of hyperlipidemia, the lipid level should be reduced to below 5.65 mmol/L as soon as possible; in the case of cholestatic pancreatitis, it is necessary to distinguish which type it is, and the principles of treatment are not identical for different types. (In non-obstructive biliary pancreatitis (the bile ducts are in a state of incomplete obstruction, that is, the bile ducts are open but not smooth), the biliary pancreatitis needs urgent surgical treatment of the biliary tract, and cannot wait. At the same time, a nutritional jejunostomy is performed, and excessive separation of peripancreatic tissues is prohibited. There is no special method for alcoholic pancreatitis. A reasonable fluid resuscitation strategy (controlled fluid resuscitation strategy) should be used to prevent severe lack of blood volume while avoiding excessive retention of body fluids in the body. In other words, after the temporary recovery of blood volume, the immediate shift is to adjust the distribution of body fluids, and the focus of fluid resuscitation is based on the clinical criterion of the disappearance of SIRS. It is necessary to unblock the intestinal tract as soon as possible by actively taking saline enemas and then giving a large amount of laxatives to unblock the bacterial toxin reservoir and reduce bacterial translocation. As long as the organism has respiratory abnormalities, regardless of the cause, mechanical ventilation should be taken, and the ventilator should be taken off early in the morning (early in the morning). Once abdominal hypertension syndrome (ACS) is present, the abdominal pressure should be reduced to less than 20 mmHg within 24 hours. The strategy has 16 words: “bowel evacuation, negative water balance, hemofiltration and surgical intervention”. The timely management of these problems within the golden 72 hours can significantly reduce hospitalization costs and improve the cure rate, but it is important that the patient is seen by the right doctor, not only at the right hospital, but also by the right doctor.