Many people have the question, are all pulmonary blisters caused by smoking? Definitely not. Smoking can cause pneumothorax, especially during outpatient follow-up and treatment, and many patients who smoke are found to have a variety of pneumothorax lesions of varying degrees on chest CT exams. In the emergency room, every year in the fall and winter, we often encounter patients with various types of pneumothorax, and these pneumothorax patients are often patients with a combination of chronic bronchial disease, emphysema, and pulmonary blisters. So, is it true that if you don’t smoke, you won’t get pneumothorax? The answer is definitely not. In clinical practice, we also encounter young people in their teens, twenties and thirties who develop pneumothorax and pulmonary blisters. There are congenital factors, but also in the growth and development of the patient’s lungs, resulting in poor development, so you can not generalize that pneumothorax must be caused by smoking, other conditions can also cause pneumothorax.