The main modes of transmission of AIDS include blood transmission, sexual transmission and vertical transmission from mother to child. The prevention of AIDS mainly includes the following: First, refuse drugs, cherish life, stay away from drugs, do not use unsterilized needles to inject drugs intravenously, which may cause HIV transmission. Second, strictly enforce the safety of blood transfusion, participate in blood donation, do not sell blood, and do not go to illegal underground blood collection points to sell blood, avoid unnecessary blood transfusion and injection, advocate the use of plasma substitutes and autologous blood transfusion, strictly sterilize medical equipment, use disposable syringes, do one person one needle, prohibit high-risk groups from donating blood, donate corneas, skin, bone marrow and internal organs to ensure the safety of the recipient. Third, when going to public places, hairdressing, beauty tools, needles need to be strictly disinfected to avoid HIV infection in the process of tattooing, ear piercing, face shaving. Fourth, in terms of sexual transmission should be clean, establish the correct moral values, and avoid risky sexual behavior. Condoms can be used to effectively prevent the spread of HIV. Fifth, after the mother is pregnant, it is recommended that pregnant women should undergo prenatal HIV testing, and those who are HIV positive should use AZT or similar drugs for treatment or termination of pregnancy. The use of cesarean delivery can reduce mother-to-child transmission. HIV-positive mothers should avoid breastfeeding after delivery and can take alternative feeding.