According to the British Broadcasting Corporation (BBC) reported on December 17, U.S. scientists recently said that they used the natural activity of the human brain to directly manipulate the prosthesis research has made a new breakthrough. Researchers published a paper in the leading medical journal The Lancet about how a woman fitted with this advanced prosthesis automatically picked up, moved and placed objects, and said its flexibility was comparable to that of a real arm. Paralysis or amputation of a limb can result in the loss of hand pointing, grasping, manipulating and moving objects, all of which are necessary in everyday life. Brain-machine interfaces may provide a solution for these loss of functions. Recently, Jennifer L Collinger, PhD, from the Pittsburgh Veteran Affair Center, the Department of Rehabilitation at Pittsburgh Medical Center (UPMC), and the Department of Biomedical Engineering at the University of Pittsburgh, realized this dream. He used a neurobiological approach to control a high-performance prosthesis by implanting electrodes within the cortex of a quadriplegic patient, a prosthesis that allows for freedom of movement in a variety of spaces. The findings are published on the front page of the latest issue of Lancet. The researchers implanted two 96-channel microelectrodes in the cortical area of the brain of a 52-year-old quadriplegic patient. This participant was evaluated by achieving seven degrees of freedom of movement (three-dimensional translation, three-dimensional rotation and one-dimensional grasping) on his prosthesis. The entire trial was conducted over 13 weeks. The participant’s ability to control the prosthesis and perform upper extremity activities was assessed by clinical methods. Participants were able to successfully utilize the prosthesis to move in three dimensions on the second day of training. At the end of 13 weeks, activities in seven dimensions could be routinely completed successfully. The success rate for tasks completed according to goal-defined was 91.6% (standard deviation 4.4) vs. a median success rate of 6.2% (95% confidence interval 2.0-15.3). Completion time also improved (from a mean of 148 s [SD60] to 112 s and pathfinding efficiency (from 0.30 [0.04] to 0.38 [0.02]). Participants were also proficient in coordination and grasping movements with the prosthesis, with significant clinical gains in upper extremity function, and no adverse effects have been reported. With advances in the field of neuroprosthetics, individuals with long-term paralysis can perform activities such as translation of the prosthetic hand, rotation, and touch through natural and intuitive command signals, which can be used to achieve self-care in daily life. It is reported that scientists are continuing to refine this prosthesis so that individuals with disabilities can use it to perceive the texture and temperature of objects.