During pregnancy, especially in the early stage of pregnancy, some pregnant mothers may have personality changes such as irritability and irritability due to heavy early pregnancy reaction, easy to work, emotional tension, and changes in hormone levels in the body, but generally rarely reach the level of irritability. If you are irritable after pregnancy, you should pay attention to whether the pregnant woman is accompanied by impatience, anxiety, excessive sweating, panic attacks and other metabolic accelerations, and first of all, you should have a thyroid function test to exclude endocrine system diseases such as hyperthyroidism. Thyroid function tests include serum TSH (thyroid stimulating hormone), FT4 (free T4), and TPOAb (thyroid peroxidase antibody) measurements. If TSH is <0.1miu/L, FT4 is normal or mildly elevated, and TPOAb is usually negative, it indicates subclinical hyperthyroidism, which is commonly caused by pregnancy and is associated with increased maternal HCG (human chorionic gonadotropin), which overstimulates thyroid hormone production. Transient hyperthyroidism during pregnancy has no effect on pregnancy. If TSH is less than 0.1miu/L, FT4 is significantly elevated and TPOAb is positive, it indicates clinical hyperthyroidism, which is commonly caused by Graves' disease; clinical hyperthyroidism with mild condition or controlled by treatment has little effect on pregnancy; clinical hyperthyroidism with severe condition or uncontrolled by treatment is prone to miscarriage, preterm delivery, stillbirth, low birth weight, gestational hypertension, thyroid crisis, and heart failure. The mother's congestive heart failure, etc. Clinical hyperthyroidism often requires treatment, with propylthiouracil (PTU) preferred in early pregnancy and methimazole (MMI) preferred in mid- to late-pregnancy and during lactation. In conclusion, the development of irritability during pregnancy, with significant changes compared to non-pregnancy, should be highly alert to the possibility of hyperthyroidism and requires prompt medical attention for a definitive diagnosis.