Irritability and irritability do not necessarily mean depression. However, if a patient has other abnormal symptoms in addition to the irritable and irritable manifestations, an affective mental illness including depression is considered. If a person has always been irritable and irritable, there may be no obvious relationship with depression. However, if a person suddenly becomes irritable, impulsive, often has great grievances or anger because of some trivial things that normal people think, and is accompanied by suspicious and sensitive, bored with social life, insecure, with large fluctuations in mood, diminished interest, or even self-harm or domestic violence and other abnormal performance, then the possibility of affective mental illness is considered. At this time, you should go to the psychology department of the hospital to seek help from the doctor as soon as possible to reduce the pain of the patient and the patient’s family and to avoid aggravation of the disease so that the patient will not make extreme actions. In conclusion, when depression is suspected after comprehensive consideration, it is recommended that anxiety and depression scales and other tests be performed, and standardized treatment should be carried out according to the test results.