The clinical manifestations of depression include three main aspects: core symptoms, psychological symptoms, and somatic symptoms. Among them, psychotic symptoms are one kind of psychological symptoms, often manifested as hallucinations, delusions or depressive rigidity. For depressed patients, if psychotic symptoms appear, it means that the degree of depression is more serious, and they should seek medical treatment in time for active treatment.1. Hallucinations: Patients may have hallucinations of invisible words and speech in the brain, and verbal hallucinations are the most common, and the voice of hallucinations can be directly talking to the patient, or the patient as a third party can hear the conversation of others. The content of the hallucinations is usually related to the patient and is mostly unfavorable to the patient, such as commenting on the patient’s words and actions, discussing the patient’s character, ordering the patient to do something dangerous, etc. 2.Delusions: mainly manifested as some negative, negative delusions, such as feeling that they have a great sin and should be severely punished; believing that they can’t do anything well and have no value; firmly believing that they have incurable cancer; feeling that they will face an unimaginable major disaster, etc. 3.Depressive wood stiffness: often caused by acute severe depression, the patient may feel depressed due to low mood and Patients may feel bulky and unable to lift their limbs due to depressed mood, but the muscle tone is tested to be normal. The patient often lacks request and initiative, and it is difficult to respond to external stimuli. 4, other: depressed patients often have some physical symptoms in addition to mental symptoms, such as sexual dysfunction, sleep disorders, autonomic dysfunction, eating disorders, etc. The above symptoms are closely related to each other, and for different patients, these symptoms may appear at the same time, or only a few of them may appear. Therefore, once the diagnosis of psychotic depression is confirmed, it is necessary to use both antidepressants and antipsychotic drugs to effectively treat psychotic depression.