The phenomenon of growing pains was first introduced by Duchamp in 1823, and has been gradually accepted and understood in recent years. Because it often occurs during the growth period, it is called “growing pains”. It is a physiological phenomenon unique to childhood, and is most common in healthy children between the ages of 2 and 12. The main manifestation is recurrent intermittent pain in both lower limbs, especially in the shin and knee joints and their surrounding areas. Typical growing pains occur in the middle of the night and last for a few minutes to two hours before being relieved. The pain is mild and does not affect daytime activities. In recent years, there has been an increase in the rate of visits to the doctor for growing pains. Although growing pains will not affect the normal growth and development of children in the intermittent period. However, many parents are still particularly worried about this. At present, there are many hypotheses about the mechanism of growing pains, so what are the main factors related to? Relationship with bone metabolism Calcium and phosphorus are important substances in the human body that affect bone production and metabolism, and are the main inorganic elements of bone composition. Some studies have used bone mineral meter to measure the forearm bone calcium content and bone density of children with growing pains. It was found that at least 82% of children in different age groups have lower than normal bone calcium content, bone density is also significantly lower, indicating that the occurrence of children’s growing pains and calcium deficiency has a certain relationship, may be due to pediatric bone development. Neuromuscular tension and lead to tugging pain, in addition, calcium on nerve excitation has inhibitory effect, calcium deficiency can make the neuromuscular excitability increase. This can cause muscle pain or muscle spasm.