Botulinum toxin (BTX) has been used in the field of aesthetics for more than 10 years, and from the reports available so far, it is very safe and effective. As a reversible treatment, it meets the principles of safety, simplicity and efficiency of medical aesthetics, and is a very popular cosmetic drug for both doctors and patients. A, the main indications for cosmetic applications 1, for the face and neck wrinkle removal. Such as forehead lines, interbrow lines, crow’s feet, nasal dorsal lines, cheek folds, etc. 2.Used for contour beauty and improve dynamic beauty. Such as correction of simple bite muscle hypertrophy and improvement of sagging corners of the mouth. 3.Used for the treatment of glandular diseases. Such as alligator tear syndrome. 4.Treatment of head and facial dystonia. Such as idiopathic blepharospasm, facial muscle twitching disorder, etc. 5.Application in ophthalmic cosmetology. Such as improving eyebrow shape, correcting eyelid and lid deformities, treating strabismus, nystagmus and TAO. II. Contraindications to application 1. Mental disorders or poor self-control, unable to cooperate with treatment. 2, Those who are allergic to any component of BTX products or to human albumin. 3.Patients suffering from myasthenia gravis. 4.Patients who have used drugs such as gentamicin, kanamycin, neomycin, streptomycin, morphine, quinine, etc. within 2 weeks are prohibited. 5.It is prohibited for those who have local infection. 6, pregnant and lactating women should not be used. 7, patients with heart, liver, lung, kidney and other organ diseases, active tuberculosis, blood diseases and other patients should be used with caution.