1.This disease is a chronic disease, and there is no special treatment method except bone marrow transplantation. 2.The occurrence of acute hemolysis and complications can be reduced by proper management, including avoiding strain and mental tension, avoiding infection and fever, avoiding drug abuse, and avoiding some triggering factors. Lian Shimei, Department of Hematology, Dalian Central Hospital 3. If there is myelodysplasia, drugs such as ATG/ALG and cyclosporine A can be tried, but all have side effects. 4. Allogeneic bone marrow transplantation is risky and must be weighed against the pros and cons. The cost of transplantation varies from case to case, at least 300,000-500,000. 5. There are reports of successful allogeneic bone marrow transplantation for PNH both at home and abroad. Complications of transplantation are probably as follows: 1. acute toxicities related to pretreatment: oral ulcers, acute gastrointestinal reactions, etc., most of which can be tolerated. 2. Infections: bacterial infections, fungal infections, viral infections, etc., which can be life-threatening in severe cases. 3.Graft-versus-host disease: acute or chronic GVHD, which can be life-threatening. The preventive and therapeutic drugs cited have large side effects, both suppressing the immunity of the body, which can secondary or aggravate the aforementioned infections. 4, hepatic venous obstruction disease, more difficult to treat. 5.Interstitial pneumonia: it is one of the serious complications. 6, hemorrhagic cystitis 7, relapse 8, transplant failure, rejection 9, etc.