In newborns, jaundice can be classified as physiological jaundice, breast milk jaundice, or pathological jaundice. For physiological jaundice and breast milk jaundice, this is a normal physiological reaction and does not usually affect BCG vaccination. If there is no progressive jaundice and no clinical abnormality, it is considered physiological jaundice, and it is recommended to consider BCG vaccination when the jaundice value is lower than 8-10 mg/dl. Later, we will confirm whether the vaccine can be given according to the primary disease, which is safer and will not cause clinical side effects. In pathological jaundice, the value of jaundice may rise significantly, even to 20 mg/dl or more, and there is a risk of bilirubin encephalopathy. Therefore, prompt treatment of the primary disease is required at this time, in some cases by blue light therapy, and in others by blood exchange. Vaccines such as BCG should not be administered until the jaundice symptoms are controlled.