For newborns, whose jaundice value drops below 5 mg/dl, hepatitis B vaccination can be considered. After the patient’s birth, if it is slightly higher than this value at the time of vaccination, it can also be injected. However, if the patient has pathological jaundice with a high jaundice value, it is recommended that the patient’s hepatitis B vaccination be postponed and that further correlation tests be performed to see if the child has biliary atresia or other biliary system disorders, or if the patient has other congenital diseases of the liver that would cause the patient to have elevated transaminases and elevated bilirubin. If biliary atresia or other diseases of the biliary tract or liver are present, the patient should be treated actively and the bilirubin should be reduced to less than 5 mg/dl after the disease has improved, so that the vaccination is safe. In addition, the child should receive a second dose of hepatitis B vaccine one month after the injection and a third dose of hepatitis B vaccine in about six months. With three doses of hepatitis B vaccine, the patient will mostly establish a self-immune protection mechanism and become immune to chronic viral hepatitis B.